Toxicity of polyamidoamine dendrimers in vivo

The development of effective drug delivery systems is a crusial task for modern medicine. main problem the occurrence non-specific toxicity leading to undesirable side effects in vivo. This article aims at reviewing resent research on polyamidoamine (PAMAM) dendrimers results show that PAMAM and modified nanoparticles depends both characteristics particles themselves (size, generation surface charge) administration parameters. It has been shown cationic small medium generations are non-toxic vivo when administered intravenously intraperitoneally mice doses up 10 mg/kg. In turn, anionic, neutral, do not exhibit toxicity, regardless route administration. Thus, by varying methods administration, dose, modifying dendrimers, decrease can be achieved, promising path towards their successfully aplication as carriers.